Ordering in alcohol and cannabis co-use: Impact on daily consumption and consequences.
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ABSTRACT: Background
Co-use of alcohol and cannabis is highly prevalent among young adults and college students. Between-person reports suggest that co-use is associated with the experience of more frequent consumption and related consequences, compared to single substance use. However, recent studies have found conflicting evidence regarding the impact of co-use use on consumption and consequences in daily or event-level investigations. Conflicting evidence may be due to understudied factors, such as the order in which alcohol and cannabis are used. The current study aimed to examine the effect of substance use order on a) alcohol consumption; b) cannabis consumption; and c) negative alcohol and cannabis consequences.Methods
Data were collected from U.S. undergraduate college student alcohol and cannabis users (N = 258) who completed two 28-day longitudinal online assessment bursts examining alcohol and cannabis co-use patterns. Data were collected five times per day during both bursts (three months apart).Results
Controlling for between-person alcohol and cannabis use, within-person mixed-effects models indicated that using cannabis first within a co-use day was associated with lower daily alcohol consumption, but greater daily cannabis consumption. Substance use ordering was not linked to consequences, whereas between-person levels of alcohol consumption and within-person number of drinks in a day were positive predictors of consequences.Conclusions
Overall, results highlighted that order of substance use is a robust predictor of consumption on co-use days. Therefore, future research on co-use use should consider patterns of use in addition to level of use.
SUBMITTER: Gunn RL
PROVIDER: S-EPMC7928210 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:BackgroundAlcohol and marijuana are frequently co-used with overlapping effects. However, the absence of consistent operational definitions delineating simultaneous alcohol and marijuana use (SAM) from concurrent use (CAM) challenges consistent inferences about these behaviors. This study first examined whether daily alcohol and marijuana co-use predicted substance-use related consequences and subjective intoxication; and then evaluated whether competing operationalizations of SAM and CAM were associated with differences in these outcomes on co-use days.MethodsA sample of 341 young adult college students who reported past-month use of both alcohol and marijuana "at the same time so that their effects overlapped" completed a two-wave survey with paired 28-day daily experience sampling bursts examining alcohol and marijuana co-use. Outcomes were (a) daily substance-use related consequences; and (b) daily subjective intoxication. Focal predictors were daily drinks and marijuana uses; daily co-use versus single-substance use (Aim 1) or CAM versus SAM (Aim 2); and their interaction.ResultsParticipants reported more negative consequences on co-use days versus marijuana-only days and greater subjective intoxication relative to alcohol or marijuana-only days. Competing operationalizations of SAM, defined as daily co-use occurring within 1-240 min in increments of 1 min, found no difference in consequences or subjective intoxication regardless of operationalization.ConclusionCo-use days involve greater risk than alcohol-only or marijuana-only days. Although there was no evidence of additional daily risk from simultaneous use regardless of the timeframe used to operationalize it, investigating these effects remains challenging due to the generally small timeframe between substances on co-use days in this sample.
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