Dataset Information

Delirium in older patients with COVID-19: prevalence, risk factors and clinical relevance.

ABSTRACT:

Background

Delirium prevalence increases with age and is associated with poor outcomes. We aimed to investigate the prevalence and risk factors for delirium in older patients hospitalized with COVID-19, as well as its association with length of stay and mortality.

Methods

Retrospective study of patients aged ? 65 years hospitalized with COVID-19. Data were collected from computerized medical records and all patients had delirium assessment at admission. Risk factors for delirium as well as the outcomes mentioned above were studied by two-group comparison, logistic regression and Cox proportional-hazard models.

Results

Of a total of 235 Caucasian patients, 48 (20.4%) presented with delirium, which was hypoactive in 41.6% of cases, hyperactive and mixed in 35.4% and 23.0%, respectively. Patients with cognitive impairment had a nearly four times higher risk of developing delirium compared to patients that were cognitively normal before SARS-CoV-2 infection (OR 3.7; 1.7-7.9 95% CI, p=0.001). The presence of delirium did not modify the time from symptoms' onset to hospitalization nor the length of stay in acute care, but it was associated with an increased risk of dying (HR 2.1; 1.2-3.7 95%CI; p=0.0113).

Conclusion

Delirium was a prevalent condition in older people admitted with COVID-19 and pre-existing cognitive impairment was its main risk factor. Delirium was associated with higher in-hospital mortality. These results highlight the importance of early recognition of delirium especially when pre-morbid cognitive comorbidities are present.

SUBMITTER: Mendes A

PROVIDER: S-EPMC7929187 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Delirium in Older Patients With COVID-19: Prevalence, Risk Factors, and Clinical Relevance.

Mendes Aline A Herrmann François R FR Périvier Samuel S Gold Gabriel G Graf Christophe E CE Zekry Dina D

The journals of gerontology. Series A, Biological sciences and medical sciences 20210701 8

<h4>Background</h4>Delirium prevalence increases with age and is associated with poor outcomes. We aimed to investigate the prevalence and risk factors for delirium in older patients hospitalized with COVID-19, as well as its association with length of stay and mortality.<h4>Method</h4>This was a retrospective study of patients aged 65 years and older hospitalized with COVID-19. Data were collected from computerized medical records and all patients had delirium assessment at admission. Risk fact ...[more]

PMID: 33539505

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