Ontology highlight
ABSTRACT:
SUBMITTER: Rao B
PROVIDER: S-EPMC7929502 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Science advances 20210303 10
Endoplasmic reticulum-associated degradation (ERAD) is a process directing misfolded proteins from the ER lumen and membrane to the degradation machinery in the cytosol. A key step in ERAD is the translocation of ER proteins to the cytosol. Derlins are essential for protein translocation in ERAD, but the mechanism remains unclear. Here, we solved the structure of human Derlin-1 by cryo-electron microscopy. The structure shows that Derlin-1 forms a homotetramer that encircles a large tunnel trave ...[more]