Ontology highlight
ABSTRACT:
SUBMITTER: Bassi TG
PROVIDER: S-EPMC7930247 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Bassi Thiago G TG Rohrs Elizabeth C EC Fernandez Karl C KC Ornowska Marlena M Nicholas Michelle M Gani Matt M Evans Doug D Reynolds Steven C SC
Scientific reports 20210303 1
Mechanical ventilation is the cornerstone of the Intensive Care Unit. However, it has been associated with many negative consequences. Recently, ventilator-induced brain injury has been reported in rodents under injurious ventilation settings. Our group wanted to explore the extent of brain injury after 50 h of mechanical ventilation, sedation and physical immobility, quantifying hippocampal apoptosis and inflammation, in a normal-lung porcine study. After 50 h of lung-protective mechanical vent ...[more]