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Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model.


ABSTRACT: Mechanical ventilation is the cornerstone of the Intensive Care Unit. However, it has been associated with many negative consequences. Recently, ventilator-induced brain injury has been reported in rodents under injurious ventilation settings. Our group wanted to explore the extent of brain injury after 50 h of mechanical ventilation, sedation and physical immobility, quantifying hippocampal apoptosis and inflammation, in a normal-lung porcine study. After 50 h of lung-protective mechanical ventilation, sedation and immobility, greater levels of hippocampal apoptosis and neuroinflammation were clearly observed in the mechanically ventilated group, in comparison to a never-ventilated group. Markers in the serum for astrocyte damage and neuronal damage were also higher in the mechanically ventilated group. Therefore, our study demonstrated that considerable hippocampal insult can be observed after 50 h of lung-protective mechanical ventilation, sedation and physical immobility.

SUBMITTER: Bassi TG 

PROVIDER: S-EPMC7930247 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model.

Bassi Thiago G TG   Rohrs Elizabeth C EC   Fernandez Karl C KC   Ornowska Marlena M   Nicholas Michelle M   Gani Matt M   Evans Doug D   Reynolds Steven C SC  

Scientific reports 20210303 1


Mechanical ventilation is the cornerstone of the Intensive Care Unit. However, it has been associated with many negative consequences. Recently, ventilator-induced brain injury has been reported in rodents under injurious ventilation settings. Our group wanted to explore the extent of brain injury after 50 h of mechanical ventilation, sedation and physical immobility, quantifying hippocampal apoptosis and inflammation, in a normal-lung porcine study. After 50 h of lung-protective mechanical vent  ...[more]

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