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Dosimetric analysis of Deep Inspiratory Breath-hold technique (DIBH) in left-sided breast cancer radiotherapy and evaluation of pre-treatment predictors of cardiac doses for guiding patient selection for DIBH.


ABSTRACT:

Introduction

The risk of radiotherapy-associated cardiovascular disease has been a concern for decades in breast cancer survivors. The objective of our study is to evaluate the dosimetric benefit of Deep Inspiratory Breath-hold technique (DIBH) on organs-at-risk (OAR) sparing in left-sided breast cancer radiotherapy and to find out pre-treatment predictors of cardiac doses for guiding patient selection for DIBH.

Material and methods

Pre-radiotherapy planning CT scans were done in Free Breathing (FB) and in DIBH [using Active Breathing Coordinator system (ABC™)] in 31 left sided breast cancer patients. 3DCRT plans were generated for both scans. Comparison of anatomical and dosimetric variables were done using paired t test and correlation was evaluated using Pearson correlation. Linear regression was used to get independent predictors of cardiac sparing and Receiver Operating Characteristic (ROC) curve analysis was done to find out the specific threshold of the predictors.

Results

There was a 39.15% reduction in mean heart dose in DIBH compared to FB (2.4?Gy vs 4.01?Gy) (p?ConclusionDIBH leads to significant reduction in OAR doses and is suggested for all patients of left-sided breast cancer undergoing radiotherapy. However, HVIF and MHD predicted for cardiac sparing and threshold criteria of ?HVIF and ?MHD may be used by centres with high workload to select patients for DIBH.

SUBMITTER: Ferdinand S 

PROVIDER: S-EPMC7930610 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Dosimetric analysis of Deep Inspiratory Breath-hold technique (DIBH) in left-sided breast cancer radiotherapy and evaluation of pre-treatment predictors of cardiac doses for guiding patient selection for DIBH.

Ferdinand Soujanya S   Mondal Monidipa M   Mallik Suman S   Goswami Jyotirup J   Das Sayan S   Manir Kazi S KS   Sen Arijit A   Palit Soura S   Sarkar Papai P   Mondal Subhayan S   Das Suresh S   Pal Bipasha B  

Technical innovations & patient support in radiation oncology 20210301


<h4>Introduction</h4>The risk of radiotherapy-associated cardiovascular disease has been a concern for decades in breast cancer survivors. The objective of our study is to evaluate the dosimetric benefit of Deep Inspiratory Breath-hold technique (DIBH) on organs-at-risk (OAR) sparing in left-sided breast cancer radiotherapy and to find out pre-treatment predictors of cardiac doses for guiding patient selection for DIBH.<h4>Material and methods</h4>Pre-radiotherapy planning CT scans were done in  ...[more]

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