Dataset Information

Active and Strippable PVA/Borax/NaBO₃ Hydrogel for Effective Containment and Decontamination of Chemical Warfare Agents.

ABSTRACT: Active gels present unique potential for the decontamination of chemical warfare agents (CWAs) as they strongly adhere to surfaces, thus allowing prolonged decontamination time. Herein, we present a decontamination hydrogel based on polyvinyl alcohol/borax, which contains sodium perborate (NaBO₃), as an in situ source of the active ingredient hydrogen peroxide. Developed as a binary formulation, this gel instantly forms and effectively sticks when sprayed on various matrices, including porous and vertically positioned matrices. The gel efficiently detoxified the CWAs sarin (GB), O-ethyl S-2-(diisopropylamino)ethyl methylphosphonothioate (VX), and sulfur mustard (HD) in test tubes (2 ?L CWA/0.5 mL gel) to provide nontoxic products with reaction half-lives of <3, 45 and 113 min, respectively. The gel was also shown to efficiently decontaminate surfaces contaminated with VX (5-7 mg, 8-12 mL of gel, i.e., >99%) and to prevent GB evaporation, as proven by laboratory wind tunnel experiments. The universal decontamination abilities of this mild hydrogel, as well as its facile application and removal processes suggest that it holds high potential for future development as a new CWA decontamination tool.

SUBMITTER: Redy Keisar O

PROVIDER: S-EPMC7931205 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Active and Strippable PVA/Borax/NaBO<sub>3</sub> Hydrogel for Effective Containment and Decontamination of Chemical Warfare Agents.

Redy Keisar Orit O Nahum Victoria V Yehezkel Lea L Marcovitch Itzhak I Columbus Ishay I Fridkin Gil G Chen Ravit R

ACS omega 20210216 8

Active gels present unique potential for the decontamination of chemical warfare agents (CWAs) as they strongly adhere to surfaces, thus allowing prolonged decontamination time. Herein, we present a decontamination hydrogel based on polyvinyl alcohol/borax, which contains sodium perborate (NaBO<sub>3</sub>), as an in situ source of the active ingredient hydrogen peroxide. Developed as a binary formulation, this gel instantly forms and effectively sticks when sprayed on various matrices, includin ...[more]

PMID: 33681575

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Project description:The organophosphorus chemical warfare agents were initially synthesized in the 1930's and are some of the most toxic compounds ever discovered. The standard means of decontamination are either harsh chemical hydrolysis or high temperature incineration. Given the continued use of chemical warfare agents there are ongoing efforts to develop gentle environmentally friendly means of decontamination and medical counter measures to chemical warfare agent intoxication. Enzymatic decontamination offers the benefits of extreme specificity and mild conditions, allowing their use for both environmental and medical applications. The most promising enzyme for decontamination of the organophosphorus chemical warfare agents is the enzyme phosphotriesterase from Pseudomonas diminuta. However, the catalytic activity of the wild-type enzyme with the chemical warfare agents falls far below that seen with its best substrates, and its stereochemical preference is for the less toxic enantiomer of the chiral phosphorus center found in most chemical warfare agents. Rational design efforts have succeeded in the dramatic improvement of the stereochemical preference of PTE for the more toxic enantiomers. Directed evolution experiments, including site-saturation mutagenesis, targeted error-prone PCR, computational design, and quantitative library analysis, have systematically improved the catalytic activity against the chemical warfare nerve agents. These efforts have resulted in greater than 4-orders of magnitude improvement in catalytic activity and have led to the identification of variants that are highly effective at detoxifying both G-type and V-type nerve agents. The best of these variants have the ability to prevent intoxication when delivered as a post-exposure treatment for VX and as a pre-exposure treatment for G-agent intoxication with observed protective factors up to 60-fold. Combining the best variant, H257Y/L303T, with a PCB polymer coating has enabled the development of a long lasting circulating prophylactic treatment that is highly effective against sarin.

Dataset Information

Active and Strippable PVA/Borax/NaBO₃ Hydrogel for Effective Containment and Decontamination of Chemical Warfare Agents.

Publications

Active and Strippable PVA/Borax/NaBO<sub>3</sub> Hydrogel for Effective Containment and Decontamination of Chemical Warfare Agents.

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Dataset Information

Active and Strippable PVA/Borax/NaBO3 Hydrogel for Effective Containment and Decontamination of Chemical Warfare Agents.

Publications

Active and Strippable PVA/Borax/NaBO<sub>3</sub> Hydrogel for Effective Containment and Decontamination of Chemical Warfare Agents.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

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Active and Strippable PVA/Borax/NaBO₃ Hydrogel for Effective Containment and Decontamination of Chemical Warfare Agents.