Dataset Information

Encapsulation of an Anionic Surfactant into Hollow Spherical Nanosized Capsules: Size Control, Slow Release, and Potential Use for Enhanced Oil Recovery Applications and Environmental Remediation.

ABSTRACT: A new platform that allows encapsulation of anionic surfactants into nanosized capsules and subsequent release upon deployment is described. The system is based on DOWFAX surfactant molecules incorporated into sub-100 nm hollow silica nanoparticles composed of a mesoporous shell. The particles released 40 wt % of the encapsulated surfactant at 70 °C compared to 24 wt % at 25 °C after 21 and 18 days, respectively. The use of the particles for subsurface applications is assessed by studying the effectiveness of the particles to alter the wettability of hydrophobic surfaces and reduction of the interfacial tension. The release of the surfactant molecules in the suspension reduces the contact angle of a substrate from 105 to 25° over 55 min. A sustained release profile is demonstrated by a continuous reduction of the interfacial tension of an oil suspension, where the interfacial tension is reduced from 62 to 2 mN m^-1 over a period of 3 days.

SUBMITTER: Alsmaeil AW

PROVIDER: S-EPMC7931374 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Encapsulation of an Anionic Surfactant into Hollow Spherical Nanosized Capsules: Size Control, Slow Release, and Potential Use for Enhanced Oil Recovery Applications and Environmental Remediation.

Alsmaeil Ahmed Wasel AW Hammami Mohammed Amen MA Enotiadis Apostolos A Kanj Mazen Yousef MY Giannelis Emmanuel P EP

ACS omega 20210219 8

A new platform that allows encapsulation of anionic surfactants into nanosized capsules and subsequent release upon deployment is described. The system is based on DOWFAX surfactant molecules incorporated into sub-100 nm hollow silica nanoparticles composed of a mesoporous shell. The particles released 40 wt % of the encapsulated surfactant at 70 °C compared to 24 wt % at 25 °C after 21 and 18 days, respectively. The use of the particles for subsurface applications is assessed by studying the ef ...[more]

PMID: 33681608

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Project description:Rhinoviruses (RVs) are major instigators of acute exacerbations of asthma, COPD and other respiratory diseases. RVs are categorized into three species (RV-A, RV-B, and RV-C), which comprise more than 160 serotypes, making it difficult to develop an effective vaccine. Currently no effective treatment for RV infection is available. Pulmonary surfactant is an extracellular complex of lipids and proteins that plays a central role in regulating innate immunity in the lung. The minor pulmonary surfactant lipids, palmitoyl-oleoyl-phosphatidylglycerol (POPG) and phosphatidylinositol (PI), are potent regulators of inflammatory processes, and exert antiviral activity against respiratory syncytial virus (RSV) and influenza A viruses (IAV). In the current study, we examined the potencies of POPG and PI against rhinovirus A16 (RV-A16) in primary human airway epithelial cells (AECs) differentiated at an air-liquid interface (ALI). After AECs were infected with RV-A16, PI reduced viral RNA copy number by 80% and downregulated (55-65%) expression of antiviral genes (MDA5, IRF7 and IFN-lambda). In contrast, POPG only slightly decreased MDA5 (24%) and IRF7 (11%) gene expression but did not inhibit IFN-lambda gene expression or RV-A16 replication in AECs. However, both POPG and PI inhibited (50-80%) IL6 and CXCL11 gene expression and protein secretion. PI treatment dramatically attenuated global gene expression changes induced by RV-A16 infection in AECs. Cell type enrichment analysis of viral regulated genes opposed by PI treatment revealed that PI inhibited viral induction of goblet cell metaplasia and virus-induced downregulation of ciliated, club, and ionocyte cell types. Notably, PI treament altered the ability of RV-A16 to regulate expression of some phosphatidylinositol 4-kinase (PI4K), acyl-CoA binding domain containing (ACBD) and low density lipoprotein receptor (LDLR) genes that play critical roles in the formation and functioning of replication organelles (ROs) required for RV replication in host cells. These data suggest PI can be used as a potent, non-toxic antiviral agent for RV infection prophylaxis and treatment.

Dataset Information

Encapsulation of an Anionic Surfactant into Hollow Spherical Nanosized Capsules: Size Control, Slow Release, and Potential Use for Enhanced Oil Recovery Applications and Environmental Remediation.

Publications

Encapsulation of an Anionic Surfactant into Hollow Spherical Nanosized Capsules: Size Control, Slow Release, and Potential Use for Enhanced Oil Recovery Applications and Environmental Remediation.

Similar Datasets

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