Ontology highlight
ABSTRACT:
SUBMITTER: Genaro-Mattos TC
PROVIDER: S-EPMC7931400 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Genaro-Mattos Thiago C TC Anderson Allison A Allen Luke B LB Korade Zeljka Z Mirnics Károly K
ACS omega 20210217 8
The last step of cholesterol biosynthesis is the conversion of 7-dehydrocholesterol (7-DHC) into cholesterol, a reaction catalyzed by dehydrocholesterol reductase 7 (DHCR7). Investigation of the effect of <i>Dhcr</i>7 single-allele mutations on the metabolism of aripiprazole (ARI) and cariprazine (CAR) in maternally exposed transgenic pups revealed that ARI, CAR, and their active metabolites were decreased in the liver and brain of <i>Dhcr</i>7 <sup><i>+/-</i></sup> . This difference in the drug ...[more]