Practical and Sustainable Modification Method on Activated Carbon to Improve the Decolorization Process in the Acetaminophen Pharmaceutical Industry.

ABSTRACT: Decolorization plays an important part in the industrial production of acetaminophen (APAP) drugs. The impurities generated from the APAP pharmaceutical industry decolorization refining process were primarily separated and purified, and their structures were determined by MS and ¹H NMR technology. Then the catalytic effects of three samples of modified powdered activated carbon (PAC) on APAP in heterogeneous solution systems and the adsorption catalysis system were systematically investigated, which indicated that PAC catalyzed the APAP oxidative coupling side reaction and thus increased the impurities in the APAP product. The M-T-RAC (thermal regeneration PAC modified by ammonium sulfate) possessing more acidic surface groups can effectively inhibit this side reaction. Furthermore, according to the different catalytic results of O-T-RAC (thermal regeneration PAC modified by hydrogen peroxide) in solid-liquid catalytic and adsorption catalytic systems, we speculated that the multimer impurities were generated by the oxidative coupling reaction of APAP being oxidized to rated N-acetyl-p-benzoquinone (NAPQI) during decolorization, while free radical polymerization of APAP mainly occurred in the pores of the spent PAC. The pore textural structure and chemical properties of M-T-RAC were further characterized to ensure its feasibility of industrial application. The process of simulating industrial decolorization substantiated the excellent ability of M-T-RAC to inhibit side reactions. This study contributes to the development of green materials for sustainable recycling of activated carbon to reduce pollution and costs, and provides an effective advice for the pharmaceutical process.

SUBMITTER: Liu H 

PROVIDER: S-EPMC7931432 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature