Systematic review of available software for multi-arm multi-stage and platform clinical trial design.

ABSTRACT:

Background

In recent years, the popularity of multi-arm multi-stage, seamless adaptive, and platform trials has increased. However, many design-related questions and questions regarding which operating characteristics should be evaluated to determine the potential performance of a specific trial design remain and are often further complicated by the complexity of such trial designs.

Methods

A systematic search was conducted to review existing software for the design of platform trials, whereby multi-arm multi-stage trials were also included. The results of this search are reported both on the literature level and the software level, highlighting the software judged to be particularly useful.

Results

In recent years, many highly specialized software packages targeting

SUBMITTER: Meyer EL 

PROVIDER: S-EPMC7931508 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature