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Predicting Hemolytic Uremic Syndrome and Renal Replacement Therapy in Shiga Toxin-producing Escherichia coli-infected Children.


ABSTRACT:

Background

Shiga toxin-producing Escherichia coli (STEC) infections are leading causes of pediatric acute renal failure. Identifying hemolytic uremic syndrome (HUS) risk factors is needed to guide care.

Methods

We conducted a multicenter, historical cohort study to identify features associated with development of HUS (primary outcome) and need for renal replacement therapy (RRT) (secondary outcome) in STEC-infected children without HUS at initial presentation. Children aged <18 years who submitted STEC-positive specimens between January 2011 and December 2015 at a participating study institution were eligible.

Results

Of 927 STEC-infected children, 41 (4.4%) had HUS at presentation; of the remaining 886, 126 (14.2%) developed HUS. Predictors (all shown as odds ratio [OR] with 95% confidence interval [CI]) of HUS included younger age (0.77 [.69-.85] per year), leukocyte count ?13.0 × 103/?L (2.54 [1.42-4.54]), higher hematocrit (1.83 [1.21-2.77] per 5% increase) and serum creatinine (10.82 [1.49-78.69] per 1 mg/dL increase), platelet count <250 × 103/?L (1.92 [1.02-3.60]), lower serum sodium (1.12 [1.02-1.23 per 1 mmol/L decrease), and intravenous fluid administration initiated ?4 days following diarrhea onset (2.50 [1.14-5.46]). A longer interval from diarrhea onset to index visit was associated with reduced HUS risk (OR, 0.70 [95% CI, .54-.90]). RRT predictors (all shown as OR [95% CI]) included female sex (2.27 [1.14-4.50]), younger age (0.83 [.74-.92] per year), lower serum sodium (1.15 [1.04-1.27] per mmol/L decrease), higher leukocyte count ?13.0 × 103/?L (2.35 [1.17-4.72]) and creatinine (7.75 [1.20-50.16] per 1 mg/dL increase) concentrations, and initial intravenous fluid administration ?4 days following diarrhea onset (2.71 [1.18-6.21]).

Conclusions

The complex nature of STEC infection renders predicting its course a challenge. Risk factors we identified highlight the importance of avoiding dehydration and performing close clinical and laboratory monitoring.

SUBMITTER: McKee RS 

PROVIDER: S-EPMC7931832 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Predicting Hemolytic Uremic Syndrome and Renal Replacement Therapy in Shiga Toxin-producing Escherichia coli-infected Children.

McKee Ryan S RS   Schnadower David D   Tarr Phillip I PI   Xie Jianling J   Finkelstein Yaron Y   Desai Neil N   Lane Roni D RD   Bergmann Kelly R KR   Kaplan Ron L RL   Hariharan Selena S   Cruz Andrea T AT   Cohen Daniel M DM   Dixon Andrew A   Ramgopal Sriram S   Rominger Annie A   Powell Elizabeth C EC   Kilgar Jennifer J   Michelson Kenneth A KA   Beer Darcy D   Bitzan Martin M   Pruitt Christopher M CM   Yen Kenneth K   Meckler Garth D GD   Plint Amy C AC   Bradin Stuart S   Abramo Thomas J TJ   Gouin Serge S   Kam April J AJ   Schuh Abigail A   Balamuth Fran F   Hunley Tracy E TE   Kanegaye John T JT   Jones Nicholas E NE   Avva Usha U   Porter Robert R   Fein Daniel M DM   Louie Jeffrey P JP   Freedman Stephen B SB  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20200401 8


<h4>Background</h4>Shiga toxin-producing Escherichia coli (STEC) infections are leading causes of pediatric acute renal failure. Identifying hemolytic uremic syndrome (HUS) risk factors is needed to guide care.<h4>Methods</h4>We conducted a multicenter, historical cohort study to identify features associated with development of HUS (primary outcome) and need for renal replacement therapy (RRT) (secondary outcome) in STEC-infected children without HUS at initial presentation. Children aged <18 ye  ...[more]

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