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Pandemic Uropathogenic Fluoroquinolone-resistant Escherichia coli Have Enhanced Ability to Persist in the Gut and Cause Bacteriuria in Healthy Women.

ABSTRACT: We report that fluoroquinolone-resistant Escherichia coli are found in feces of 8.8% of healthy women, with most bacteria belonging to pandemic multidrug-resistant ST131-H30R or ST1193 clonal groups. Moreover, these highly uropathogenic clonal groups demonstrate an especially prolonged gut persistence and high rate of bacteriuria without documented urinary tract infection.

SUBMITTER: Tchesnokova VL

PROVIDER: S-EPMC7931843 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Pandemic Uropathogenic Fluoroquinolone-resistant Escherichia coli Have Enhanced Ability to Persist in the Gut and Cause Bacteriuria in Healthy Women.

Tchesnokova Veronika L VL Rechkina Elena E Chan Diana D Haile Helen Ghirmai HG Larson Lydia L Ferrier Kendra K Schroeder David W DW Solyanik Thalia T Shibuya Spencer S Hansen Kelly K Ralston James D JD Riddell Kim K Scholes Delia D Sokurenko Evgeni V EV

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20200201 5

We report that fluoroquinolone-resistant Escherichia coli are found in feces of 8.8% of healthy women, with most bacteria belonging to pandemic multidrug-resistant ST131-H30R or ST1193 clonal groups. Moreover, these highly uropathogenic clonal groups demonstrate an especially prolonged gut persistence and high rate of bacteriuria without documented urinary tract infection. ...[more]

PMID: 31271206

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