Ontology highlight
ABSTRACT:
SUBMITTER: Koenig PA
PROVIDER: S-EPMC7932109 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20210112 6530
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread, with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. In this study, we generated four neutralizing nanobodies that target the receptor binding domain of the SARS-CoV-2 spike protein. We used x-ray crystallography and cryo-electron microscopy to define two distinct binding epitopes. On the basis of these structu ...[more]