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Development of a novel index to characterise arterial dynamics using ultrasound imaging.


ABSTRACT: Abdominal aortic aneurysms (AAA) are associated with systemic inflammation and endothelial dysfunction. We previously reported flow mediated dilatation (FMD) of the brachial artery as a predictor of AAA growth. We hence hypothesised that other physical characteristics of the brachial artery correlate with AAA growth. Using a prospectively cohort of AAA patients, we devised a 'brachial artery relaxation index' (BARI) and examined its role as a biomarker for AAA growth. However, no correlation between BARI and future aneurysm growth was observed (p = 0.45). Therefore, our investigations did not substantiate the hypothesis that other physical characteristics of the brachial artery predicts AAA growth.

SUBMITTER: Ward J 

PROVIDER: S-EPMC7932503 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Development of a novel index to characterise arterial dynamics using ultrasound imaging.

Ward Joel J   Cheng Xinghao X   Xiao Yingyi Y   Lapolla Pierfrancesco P   Chandrashekar Anirudh A   Handa Ashok A   Cleveland Robin A RA   Lee Regent R  

PloS one 20210304 3


Abdominal aortic aneurysms (AAA) are associated with systemic inflammation and endothelial dysfunction. We previously reported flow mediated dilatation (FMD) of the brachial artery as a predictor of AAA growth. We hence hypothesised that other physical characteristics of the brachial artery correlate with AAA growth. Using a prospectively cohort of AAA patients, we devised a 'brachial artery relaxation index' (BARI) and examined its role as a biomarker for AAA growth. However, no correlation bet  ...[more]

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