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ABSTRACT: Key points
Psychiatric signs are common in inherited metabolic disorders (IMDs) and may occur in the same age-range as other clinical manifestations.Three clusters of psychiatric signs and two clusters of neurocognitive domains can be defined according to their mean age of onset.Warning signs to be used in liaison psychiatry should include age-specific cognitive impairments.
SUBMITTER: Medjkane F
PROVIDER: S-EPMC7932863 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Medjkane François F Bohet Marine M Ister Marielle M Cohen David D Parenti Aesa A Janati Majda M Mention Karine K Dobbelaere Dries D Jardri Renaud R
JIMD reports 20210209 1
Inherited metabolic disorders (IMDs) can present with psychiatric signs that vary widely from one disease to another. This picture is further complicated by the fact that these features occur at very different illness time points, which may further delay appropriate diagnosis and treatment. In this case series of 62 children and adolescents suffering from IMDs, we clustered psychiatric signs (on the basis of the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders classifi ...[more]