A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis.

ABSTRACT: Classification of acute lymphoblastic and myeloid leukemias (ALL and AML) remains heavily based on phenotypic resemblance to normal hematopoietic precursors. This framework can provide diagnostic challenges for immunophenotypically heterogeneous immature leukemias, and ignores recent advances in understanding of developmental multipotency of diverse normal hematopoietic progenitor populations that are identified by transcriptional signatures. We performed transcriptional analyses of a large series of acute myeloid and lymphoid leukemias and detected significant overlap in gene expression between cases in different diagnostic categories. Bioinformatic classification of leukemias along a continuum of hematopoietic differentiation identified leukemias at the myeloid/T-lymphoid interface, whic

SUBMITTER: Bond J 

PROVIDER: S-EPMC7932917 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature