Ontology highlight
ABSTRACT:
SUBMITTER: Weeks SE
PROVIDER: S-EPMC7933177 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Weeks Shannon E SE Kammerud Sarah C SC Metge Brandon J BJ AlSheikh Heba A HA Schneider David A DA Chen Dongquan D Wei Shi S Mobley James A JA Ojesina Akinyemi I AI Shevde Lalita A LA Samant Rajeev S RS
Cell death & disease 20210304 3
Triple-negative breast cancer (TNBC) patients with upregulated Wnt/β-catenin signaling often have poor clinical prognoses. During pathological examinations of breast cancer sections stained for β-catenin, we made the serendipitous observation that relative to non-TNBC, specimens from TNBC patients have a greater abundance of nucleoli. There was a remarkable direct relationship between nuclear β-catenin and greater numbers of nucleoli in TNBC tissues. These surprising observations spurred our inv ...[more]