Metabolic parameters in smokers undergoing smoking reduction.

ABSTRACT:

Introduction

Few human studies have explored the mechanisms of smoking-induced insulin resistance. Aims: To prospectively examine the metabolic changes of smoking reduction.

Methods

Cigarette smokers (n = 22; ½-2 packs per day) were enrolled in a smoking reduction program (counseling plus bupropion × 8 weeks; Phase I) followed by monitoring only (no counseling or bupropion × 16 weeks; Phase II). We serially measured exhaled carbon monoxide (CO) and urine nicotine metabolites; fat distribution, and metabolic parameters by hyperinsulinemic clamps including hepatic glucose output (HGO) and indirect calorimetry, adjusted for total caloric intake and expenditure.

Results

CO and nicotine metabolite levels fell with smoking reduction during Phase I (all p < 0.05), wit

SUBMITTER: Hsia SH 

PROVIDER: S-EPMC7933731 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature