Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC7933932 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Chen Haiyan H Chen Liubo L Wang Xin X Ge Xiaoxu X Sun Lifeng L Wang Zhanhuai Z Xu Xiaoming X Song Yongmao Y Chen Jing J Deng Qun Q Xie Haiting H Chen Ting T Chen Yan Y Ding Kefeng K Wu Jingjing J Wang Jian J
Journal of cellular and molecular medicine 20210124 5
Integrins, as a large family of cell adhesion molecules, play a crucial role in maintaining intestinal homeostasis. In inflammatory bowel disease (IBD), homeostasis is disrupted. Integrin αvβ6, which is mainly regulated by the integrin β6 subunit gene (ITGB6), is a cell adhesion molecule that mediates cell-cell and cell-matrix interactions. However, the role of ITGB6 in the pathogenesis of IBD remains elusive. In this study, we found that ITGB6 was markedly upregulated in inflamed intestinal tis ...[more]