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Intolerance of uncertainty, depression and the error-related negativity.

ABSTRACT: Prior work has yielded contradictory findings regarding the association between depression and the error-related negativity (ERN), an event-related potential thought to reflect individual variation in sensitivity to internal threat (i.e., errors), and the error positivity (Pe), which is thought to reflect more elaborative, conscious processing of errors. One possibility is that variation in transdiagnostic dimensional constructs related to threat processing might help explain inconsistencies in the relationship between depression and the ERN and Pe. Here, we used a large, unselected sample (N = 100) to determine whether variation in intolerance of uncertainty (IU), a transdiagnostic trait dimension that is implicated in both depression and anxiety, might moderate associations between depressive symptomatology and error processing. Results showed that greater levels of depressive symptomatology were associated with larger ΔERNs (error minus correct trials) when IU was low, but were unrelated to ΔERN when IU was high; main effects of depression and IU on ΔERN were not observed. The Pe was not associated with IU or depression. Additionally, IU, but not depression, was associated with faster response times on error and correct trials. Overall, results suggest that error processing may differ for individuals with elevated depression with versus without elevated IU. Moreover, prior failures to observe associations between depression and the ERN might stem from failure to account for related transdiagnostic constructs.

SUBMITTER: Ruchensky JR

PROVIDER: S-EPMC7934182 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundDeficits in error processing are reflected in an inability of people with externalizing problems to adjust their problem behaviour. The present study contains 2 meta-analyses, testing whether error processing - indexed by the event-related potentials error-related negativity (ERN) and error positivity (Pe) - is reduced in children and adults with externalizing problems and disorders compared to healthy controls.MethodsWe conducted a systematic search in PubMed (1980 to December 2018), PsycInfo (1980 to December 2018) and Scopus (1970 to December 2018), identifying 328 studies. We included studies that measured error processing using the Eriksen flanker task, the go/no-go task or the stop-signal task in healthy controls and in adults or children with clearly described externalizing behavioural problems (e.g., aggression) or a clinical diagnosis on the externalizing spectrum (e.g., addiction).ResultsRandom-effect models (ERN: 23 studies, 1739 participants; Pe: 27 studies, 1456 participants) revealed a reduced ERN amplitude (Hedges' g = 0.44, 95% confidence interval [CI] 0.29 to 0.58) and a reduced Pe amplitude (Hedges' g = -0.27, 95% CI -0.44 to -0.09) during error processing in people with externalizing problems or disorders compared to healthy controls. Type of diagnosis, age and the presence of performance feedback or comorbidity did not moderate the results. The employed cognitive task was a moderator for Pe but not for ERN. The go/no-go task generated a greater amplitude difference in Pe than the Eriksen flanker task. Small-sample assessment revealed evidence of publication bias for both event-related potentials. However, a p curve analysis for ERN showed that evidential value was present; for Pe, the p curve analysis was inconclusive.LimitationsThe moderators did not explain the potential heterogeneity in most of the analysis, suggesting that other disorder- and patient-related factors affect error processing.ConclusionOur findings indicate the presence of compromised error processing in externalizing psychopathology, suggesting diminished activation of the prefrontal cortex during performance monitoring.

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Intolerance of uncertainty, depression and the error-related negativity.

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