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ABSTRACT: Background
Whilst there are a number of publications comparing the relationship between body mass index (BMI) of kidney transplant recipients and graft/patient survival, no study has assessed this for a French patient cohort.Methods
In this study, cause-specific Cox models were used to study patient and graft survival and several other time-to-event measures. Logistic regressions were performed to study surgical complications at 30?days post-transplantation as well as delayed graft function.Results
Among the 4691 included patients, 747 patients were considered obese with a BMI level greater than 30?kg/m2. We observed a higher mortality for obese recipients (HR?=?1.37, p =?0.0086) and higher risks of serious bacterial infections (HR?=?1.24, p =?0.0006) and cardiac complications (HR?=?1.45, p ConclusionsWe showed that obesity increased the risk of death and serious bacterial infections and cardiac complications in obese French kidney transplant recipients. Further epidemiologic studies aiming to compare obese recipients versus obese candidates remaining on dialysis are needed to improve the guidelines for obese patient transplant allocation.
SUBMITTER: Foucher Y
PROVIDER: S-EPMC7934368 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Foucher Y Y Lorent M M Albano L L Roux S S Pernin V V Le Quintrec M M Legendre C C Buron F F Morelon E E Girerd S S Ladrière M M Glotz D D Lefaucher C C Kerleau C C Dantal J J Branchereau J J Giral M M
BMC nephrology 20210305 1
<h4>Background</h4>Whilst there are a number of publications comparing the relationship between body mass index (BMI) of kidney transplant recipients and graft/patient survival, no study has assessed this for a French patient cohort.<h4>Methods</h4>In this study, cause-specific Cox models were used to study patient and graft survival and several other time-to-event measures. Logistic regressions were performed to study surgical complications at 30 days post-transplantation as well as delayed gra ...[more]