Dataset Information

Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma.

ABSTRACT:

Background

Multiple myeloma (MM) is a type of hematological malignancy affecting the functions of plasma cells. The treatment of MM patients has changed dramatically with the use of new agents. However, unfortunately, it is still incurable. Therefore, a new approach for treating MM is still needed to improve patient outcomes.

Methods

Because the histone deacetylase (HDAC) and phosphoinositide 3-kinase (PI3K) pathway is a key signal in cancer cell biology, we investigated whether dual HDAC and PI3K inhibitors could suppress the myeloma cells.

Results

Gene expression of HDACs is high in myeloma cells. CUDC-907, a dual inhibitor of PI3K and HDAC, inhibits HDAC activity. Akt activity and expression of BCL-XL, MCL-1, and NF-?B p65 were reduced by CUDC-907 in a dose-dependent manner. The number of apoptotic and caspase 3/7-positive cells also increased in the myeloma cells. Combined treatment of myeloma cells with carfilzomib and CUDC-907 increased cytotoxicity compared to that observed with each drug alone.

Conclusions

Data from this study suggested that the administration of CUDC-907 might be a powerful strategy against myeloma cells, to enhance the cytotoxic effects of proteasome inhibitors.

SUBMITTER: Okabe S

PROVIDER: S-EPMC7934550 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma.

Okabe Seiichi S Tanaka Yuko Y Gotoh Akihiko A

Experimental hematology & oncology 20210304 1

<h4>Background</h4>Multiple myeloma (MM) is a type of hematological malignancy affecting the functions of plasma cells. The treatment of MM patients has changed dramatically with the use of new agents. However, unfortunately, it is still incurable. Therefore, a new approach for treating MM is still needed to improve patient outcomes.<h4>Methods</h4>Because the histone deacetylase (HDAC) and phosphoinositide 3-kinase (PI3K) pathway is a key signal in cancer cell biology, we investigated whether d ...[more]

PMID: 33663586

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Dataset Information

Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma.

Background

Methods

Results

Conclusions

Publications

Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma.

Similar Datasets

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