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Deoxygenative C2-heteroarylation of quinoline N-oxides: facile access to ?-triazolylquinolines

ABSTRACT: A metal- and additive-free, highly efficient, step-economical deoxygenative C2-heteroarylation of quinolines and isoquinolines was achieved from readily available N-oxides and N-sulfonyl-1,2,3-triazoles. A variety of ?-triazolylquinoline derivatives were synthesized with good regioselectivity and in excellent yields under mild reaction conditions. Further, a gram-scale and one-pot synthesis illustrated the efficacy and simplicity of the developed protocol. The current transformation was also found to be compatible for the late-stage modification of natural products.

SUBMITTER: Sontakke G

PROVIDER: S-EPMC7934756 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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