Ontology highlight
ABSTRACT:
SUBMITTER: Kisalu NK
PROVIDER: S-EPMC7934869 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Kisalu Neville K NK Pereira Lais D LD Ernste Keenan K Flores-Garcia Yevel Y Idris Azza H AH Asokan Mangaiarkarasi M Dillon Marlon M MacDonald Scott S Shi Wei W Chen Xuejun X Pegu Amarendra A Schön Arne A Zavala Fidel F Balazs Alejandro B AB Francica Joseph R JR Seder Robert A RA
JCI insight 20210208 3
CIS43 is a potent neutralizing human mAb that targets a highly conserved "junctional" epitope in the Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP). Enhancing the durability of CIS43 in vivo will be important for clinical translation. Here, 2 approaches were used to improve the durability of CIS43 in vivo while maintaining potent neutralization. First, the Fc domain was modified with the LS mutations (CIS43LS) to increase CIS43 binding affinity for the neonatal Fc receptor (FcRn). C ...[more]