Ontology highlight
ABSTRACT:
SUBMITTER: Kawashima K
PROVIDER: S-EPMC7934883 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Kawashima Keigo K Isogawa Masanori M Onishi Masaya M Baudi Ian I Saito Satoru S Nakajima Atsushi A Fujita Takashi T Tanaka Yasuhito Y
JCI insight 20210208 3
Hepatitis B virus-specific (HBV-specific) CD8+ T cells fail to acquire effector functions after priming in the liver, but the molecular basis for the dysfunction is poorly understood. By comparing the gene expression profile of intrahepatically primed, dysfunctional HBV-specific CD8+ T cells with that of systemically primed, functional effector counterparts, we found that the expression of interferon-stimulated genes (ISGs) is selectively suppressed in the dysfunctional CD8+ T cells. The ISG sup ...[more]