Ontology highlight
ABSTRACT:
SUBMITTER: Khan T
PROVIDER: S-EPMC7934927 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Khan Taushif T Rahman Mahbuba M Ali Fatima Al FA Huang Susie S Y SSY Ata Manar M Zhang Qian Q Bastard Paul P Liu Zhiyong Z Jouanguy Emmanuelle E Béziat Vivien V Cobat Aurélie A Nasrallah Gheyath K GK Yassine Hadi M HM Smatti Maria K MK Saeed Amira A Vandernoot Isabelle I Goffard Jean-Christophe JC Smits Guillaume G Migeotte Isabelle I Haerynck Filomeen F Meyts Isabelle I Abel Laurent L Casanova Jean-Laurent JL Hasan Mohammad R MR Marr Nico N
JCI insight 20210222 4
Four endemic human coronaviruses (HCoVs) are commonly associated with acute respiratory infection in humans. B cell responses to these "common cold" viruses remain incompletely understood. Here we report a comprehensive analysis of CoV-specific antibody repertoires in 231 children and 1168 adults using phage immunoprecipitation sequencing. Seroprevalence of antibodies against endemic HCoVs ranged between approximately 4% and 27% depending on the species and cohort. We identified at least 136 nov ...[more]