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n-Propyl 6-amino-2,6-dideoxy-2,2-difluoro-?-d-glucopyranoside is a good inhibitor for the ?-galactosidase from E. coli.

ABSTRACT: A convenient route has been developed for the synthesis of novel 6-amino-2,2-(or 3,3-difluoro)-2-(or 3),6-dideoxy-hexopyranoses. Biological screening showed these compounds as good inhibitors for several glycosidases. Especially n-propyl 6-amino-2,6-dideoxy-2,2-difluoro-?-d-glucopyranoside (8) was an excellent competitive inhibitor for the ?-galactosidase from E. coli holding a K _i of 0.50??M.

SUBMITTER: Serbian I

PROVIDER: S-EPMC7934981 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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n-Propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside is a good inhibitor for the β-galactosidase from E. coli.

Serbian Immo I Prell Erik E Fischer Claudia C Deigner Hans-Peter HP Csuk René R

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 20210305 5

A convenient route has been developed for the synthesis of novel 6-amino-2,2-(or 3,3-difluoro)-2-(or 3),6-dideoxy-hexopyranoses. Biological screening showed these compounds as good inhibitors for several glycosidases. Especially n-propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-d-glucopyranoside (8) was an excellent competitive inhibitor for the β-galactosidase from E. coli holding a K i of 0.50 μM. ...[more]

PMID: 33716475

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