Ontology highlight
ABSTRACT:
SUBMITTER: Balmer TS
PROVIDER: S-EPMC7935485 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
eLife 20210222
Synapses of glutamatergic mossy fibers (MFs) onto cerebellar unipolar brush cells (UBCs) generate slow excitatory (ON) or inhibitory (OFF) postsynaptic responses dependent on the complement of glutamate receptors expressed on the UBC's large dendritic brush. Using mouse brain slice recording and computational modeling of synaptic transmission, we found that substantial glutamate is maintained in the UBC synaptic cleft, sufficient to modify spontaneous firing in OFF UBCs and tonically desensitize ...[more]