The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.
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ABSTRACT:
SUBMITTER: Will Castro LSEP
PROVIDER: S-EPMC7935534 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.
Will Castro Luiza S E P LSEP Pieters Wietske W Alemdehy Mir Farshid MF Aslam Muhammad A MA Buoninfante Olimpia Alessandra OA Raaijmakers Jonne A JA Pilzecker Bas B van den Berk Paul C M PCM Te Riele Hein H Medema René H RH Pedrosa Rozangela C RC Jacobs Heinz H
Frontiers in pharmacology 20210218
The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. Applying UV-Vis spectrometry we here demonstrate ABZ as a DNA intercalator. This insight led us to determine the primary mode of ABZ action in mammalian cells. As revealed by RNA sequencing, ABZ did neither grossly affect replication as analyzed by survival and replication stress ...[more]
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