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Application of novel nanomagnetic metal-organic frameworks as a catalyst for the synthesis of new pyridines and 1,4-dihydropyridines via a cooperative vinylogous anomeric based oxidation.

ABSTRACT: Herein, a new magnetic metal-organic frameworks based on Fe₃O₄ (NMMOFs) with porous and high surface area materials were synthesized. Then, NMMOFs were characterized by FT-IR, XRD, SEM, elemental mapping, energy dispersive X-ray (EDS), TG, DTG, VSM, and N₂ adsorption-desorption isotherms (BET). Fe₃O₄@Co(BDC)-NH₂ as a magnetic porous catalyst was applied for synthesis of novel fused pyridines and 1,4-dihydropyridines with pyrazole and pyrimidine moieties as suitable drug candidates under ultrasonic irradiation. The significant advantages of the presented methodology are mild, facile workup, high yields, short reaction times, high thermal stability, and reusability of the described NMMOFs catalyst.

SUBMITTER: Sepehrmansourie H

PROVIDER: S-EPMC7935861 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Application of novel nanomagnetic metal-organic frameworks as a catalyst for the synthesis of new pyridines and 1,4-dihydropyridines via a cooperative vinylogous anomeric based oxidation.

Sepehrmansourie Hassan H Zarei Mahmoud M Zolfigol Mohammad Ali MA Babaee Saeed S Rostamnia Sadegh S

Scientific reports 20210305 1

Herein, a new magnetic metal-organic frameworks based on Fe3O4 (NMMOFs) with porous and high surface area materials were synthesized. Then, NMMOFs were characterized by FT-IR, XRD, SEM, elemental mapping, energy dispersive X-ray (EDS), TG, DTG, VSM, and N2 adsorption-desorption isotherms (BET). Fe3O4@Co(BDC)-NH2 as a magnetic porous catalyst was applied for synthesis of novel fused pyridines and 1,4-dihydropyridines with pyrazole ...[more]

PMID: 33674662

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