Ontology highlight
ABSTRACT:
SUBMITTER: von Stedingk K
PROVIDER: S-EPMC7935871 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
von Stedingk Kristoffer K Stjernfelt Karl-Johan KJ Kvist Anders A Wahlström Cecilia C Kristoffersson Ulf U Stenmark-Askmalm Marie M Wiebe Thomas T Hjorth Lars L Koster Jan J Olsson Håkan H Øra Ingrid I
Scientific reports 20210305 1
Up to 10% of pediatric cancer patients harbor pathogenic germline variants in one or more cancer susceptibility genes. A recent study from the US reported pathogenic variants in 22 out of 60 analyzed autosomal dominant cancer susceptibility genes, implicating 8.5% of pediatric cancer patients. Here we aimed to assess the prevalence of germline pathogenic variants in these 22 genes in a population-based Swedish cohort and to compare the results to those described in other populations. We found pa ...[more]