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Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study.


ABSTRACT: Primary prevention of premature death is a public health concern worldwide. Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers for diseases as cancer and cardiovascular disease (CVD). This case-cohort study aimed to investigate the potential relationship between circulating miRNAs and the risk of premature death. A total of 39,242 subjects provided baseline serum samples in 1988-1990. Of these, 345 subjects who died of intrinsic disease (

SUBMITTER: Yamada H 

PROVIDER: S-EPMC7935984 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study.

Yamada Hiroya H   Suzuki Koji K   Fujii Ryosuke R   Kawado Miyuki M   Hashimoto Shuji S   Watanabe Yoshiyuki Y   Iso Hiroyasu H   Fujino Yoshihisa Y   Wakai Kenji K   Tamakoshi Akiko A  

Scientific reports 20210305 1


Primary prevention of premature death is a public health concern worldwide. Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers for diseases as cancer and cardiovascular disease (CVD). This case-cohort study aimed to investigate the potential relationship between circulating miRNAs and the risk of premature death. A total of 39,242 subjects provided baseline serum samples in 1988-1990. Of these, 345 subjects who died of intrinsic disease (< 65 years old) and for  ...[more]

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