Ontology highlight
ABSTRACT:
SUBMITTER: Aguirre Rivera J
PROVIDER: S-EPMC7936356 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Aguirre Rivera Javier J Larsson Jimmy J Volkov Ivan L IL Seefeldt A Carolin AC Sanyal Suparna S Johansson Magnus M
Proceedings of the National Academy of Sciences of the United States of America 20210301 9
The spread of antibiotic resistance is turning many of the currently used antibiotics less effective against common infections. To address this public health challenge, it is critical to enhance our understanding of the mechanisms of action of these compounds. Aminoglycoside drugs bind the bacterial ribosome, and decades of results from in vitro biochemical and structural approaches suggest that these drugs disrupt protein synthesis by inhibiting the ribosome's translocation on the messenger RNA ...[more]