Dataset Information

Cosmetic outcome of femtosecond laser-assisted pterygium surgery.

ABSTRACT:

Background

To examine the cosmetic outcome of femtosecond laser-assisted pterygium surgery (FLAPS) with conjunctival autograft (CAG) and its potential predictive factors.

Methods

This was a prospective interventional case series (NCT02866968). We included 29 patients (29 eyes) with primary pterygium who underwent FLAPS. Cosmetic outcome was graded by two graders (an ophthalmology resident and an experienced ophthalmologist) using Hirst classification system (1-4?=?excellent-poor). Weighted Cohen's kappa analysis was performed to examine the intra- and inter-rater reliability. The relationship between cosmetic outcome and various factors were determined by Spearman's correlation coefficients (r).

Results

The preoperative severity of pterygium (Tan grading system) was mild/atrophic (7%), moderate/intermediate (62%), and severe/fleshy (31%). An ultrathin CAG (mean thickness of 74.5?±?9.8??m) was fashioned intraoperatively. An excellent cosmetic outcome of FLAPS (median?±?IQR) was observed at 3?months (1.0?±?1.0) and remained similar at 6?months (1.0?±?0.0) and 12?months (1.0?±?0.0) postoperatively. At final follow-up, 27 (93%) patients achieved good-to-excellent cosmetic outcome, with 1 (3%) patient having a poor outcome due to incomplete pterygium removal. Weighted kappa analysis of Hirst grading system showed excellent intra-rater (? =?0.86-0.95) and inter-rater reliability (? =?0.84-0.88). There was a weak and borderline significant correlation between good cosmetic outcome and reduced postoperative CAG thickness (r =?0.38, P =?0.06) but not with age, gender, preoperative pterygium severity, or intraoperative CAG thickness.

Conclusions

FLAPS can result in an excellent cosmetic outcome, which may be attributed to the beneficial effect of an ultrathin CAG.

Trial registration

ClinicalTrials.gov , NCT02866968 . Registered in July 2016.

SUBMITTER: Ting DSJ

PROVIDER: S-EPMC7936441 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Cosmetic outcome of femtosecond laser-assisted pterygium surgery.

Ting Darren Shu Jeng DSJ Liu Yu-Chi YC Lee Yi Fang YF Ji Angel Jung Se AJS Tan Tien-En TE Htoon Hla M HM Mehta Jodhbir S JS

Eye and vision (London, England) 20210306 1

<h4>Background</h4>To examine the cosmetic outcome of femtosecond laser-assisted pterygium surgery (FLAPS) with conjunctival autograft (CAG) and its potential predictive factors.<h4>Methods</h4>This was a prospective interventional case series (NCT02866968). We included 29 patients (29 eyes) with primary pterygium who underwent FLAPS. Cosmetic outcome was graded by two graders (an ophthalmology resident and an experienced ophthalmologist) using Hirst classification system (1-4 = excellent-poor). ...[more]

PMID: 33673873

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Project description:PURPOSE:To report the 3-month results of a randomized trial (Femtosecond Laser-Assisted Cataract Trial [FACT]) comparing femtosecond laser-assisted cataract surgery (FLACS) with standard phacoemulsification cataract surgery (PCS). DESIGN:Multicenter, randomized controlled trial funded by the UK National Institute of Health Research (HTA 13/04/46/). PARTICIPANTS:Seven hundred eighty-five patients with age-related cataract. METHODS:This trial took place in 3 hospitals in the UK National Health Service (NHS). Randomization (1:1) was stratified by site, surgeon, and 1 or both eyes eligible using a secure web-based system. Postoperative assessments were masked to the allocated intervention. The primary outcome was unaided distance visual acuity (UDVA) in the study eye at 3 months. Secondary outcomes included corrected distance visual acuity, complications, and patient-reported outcomes measures. The noninferiority margin was 0.1 logarithm of the minimum angle of resolution (logMAR). ISRCTN.com registry, number ISRCTN77602616. MAIN OUTCOME MEASURES:We enrolled 785 participants between May 2015 and September 2017 and randomly assigned 392 to FLACS and 393 to PCS. At 3 months postoperatively, mean UDVA difference between treatment arms was -0.01 logMAR (-0.05 to 0.03), and mean corrected distance visual acuity difference was -0.01 logMAR (95% confidence interval [CI], -0.05 to 0.02). Seventy-one percent of both FLACS and PCS cases were within ±0.5 diopters (D) of the refractive target, and 93% of FLACS and 92% of PCS cases were within ±1.0 D. There were 2 posterior capsule tears in the PCS arm and none in the FLACS arm. There were no significant differences between arms for any secondary outcome. CONCLUSIONS:Femtosecond laser-assisted cataract surgery is not inferior to conventional PCS surgery 3 months after surgery. Both methods are as good in terms of vision, patient-reported health, and safety outcomes at 3 months. Longer-term outcomes of the clinical effectiveness and cost-effectiveness are awaited.

Project description:BackgroundOptical quality and macular thickness changing optical quality is rarely reported after femtosecond laser-assisted cataract surgery (FLACS). In current research, we evaluated optical quality recovery and distinct macular thickness changes after FLACS and phacoemulsification cataract surgery (PCS).MethodsA total of 100 cataract patients (100 eyes) were included (50 eyes for the FLACS group and 50 eyes for the PCS group). Modulation transfer function (MTF), point spread function (PSF) and dysfunctional lens index (DLI) were measured by a ray-tracing aberrometer (iTrace). Uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) were also assessed pre-operation,1?week and 1?month after surgery. The MTF values at spatial frequencies of 5, 10, 15, 20, 25 and 30?cycles/degree (c/d) were selected. We used optical coherence tomography (OCT) to assess the macular thickness of different regions pre-operatively and1month after the surgery.ResultsIn PCS group, we found the statistically significant differences between pre-operation and post-operation in DLI (p?<?0.0001), PSF (strehl ratio, SR) (p?= 0.027) and MTF (p?=?0.028), but not intraocular pressure (IOP) (p?=?0.857). The differences between pre-operation and post-operation for DLI (p?=?0.031), SR (p?=?0.01) and IOP (p?=?0.03), but not MTF (p?=?0.128) were also found in FLACS group. The differences were statistically significant when the spatial frequencies were at 5, 10 and 25 (p?=?0.013, 0.031 and 0.048) between pre-operation and post-operation in PCS group but not FLACS group at 1?month. In PCS group, we found the differences between pre-operation and post-operation in nasal inter macular ring thickness (NIMRT) (p?=?0.03), foveal volume (FV) (p?=?0.034) and average retinal thickness (ART) (p?=?0.025) but not FLACS group at 1?month.ConclusionFLACS is safe that did not cause significant increase of macular thickness in current study. However, it also cannot produce better optical quality. In contrast, PCS can produce macular thickness changes, but better optical quality recovery. The slightly retinal change may not affect optical quality.

Dataset Information

Cosmetic outcome of femtosecond laser-assisted pterygium surgery.

Background

Methods

Results

Conclusions

Trial registration

Publications

Cosmetic outcome of femtosecond laser-assisted pterygium surgery.

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