Estimated glomerular filtration rate and postoperative mortality in patients undergoing non-cardiac and non-neuron surgery: a single-center retrospective study.

ABSTRACT:

Background

There is limited evidence to clarify the specific relationship between preoperative estimated glomerular filtration rate (preop-eGFR) and postoperative 30-day mortality in Asian patients undergoing non-cardiac and non-neuron surgery. We aimed to investigate details of this relationship.

Methods

We reanalyzed a retrospective analysis of the clinical records of 90,785 surgical patients at the Singapore General Hospital from January 1, 2012 to October 31, 2016. The main outcome was postoperative 30-day mortality.

Results

The average age of these recruited patients was 53.96?±?16.88 years, of which approximately 51.64% were female. The mean of preop-eGFR distribution was 84.45?±?38.56 mL/min/1.73 m². Multivariate logistic regression analysis indicated that preop-eGFR was independently associated with 30-day mortality (adjusted odds ratio: 0.992; 95% confidence interval [CI] 0.990-0.995; P?DiscussionThe relationship between preop-eGFR and 30-day mortality is U-shaped. The recommended preop-eGFR at which the rate of the 30-day mortality was lowest was 98.688 mL/min/1.73 m².

SUBMITTER: Luo X 

PROVIDER: S-EPMC7936476 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature