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ABSTRACT: Background
Interstitial lung disease is a common complication of systemic sclerosis (SSc-ILD), and it remains difficult to accurately predict its course. Progressing ILD could be more metabolically active, suggesting that the 18F-FDG tracer could be a tool in the managing of SSc-ILD.Methods
In our center, SSc patients and controls (non-Hodgkin lymphoma cured after first-line regimen) who had received a PET/CT were screened retrospectively. The FDG uptake (visual intensity, pattern, SUVmax) was systematically recorded in >?30 regions of interest (ROIs) linked to SSc in a blind reviewing by 2 independent nuclear medicine physicians using a standardized form.Results
Among the 545 SSc patients followed up in our center, 36, including 22 SSc-ILDs, had a PET/CT, whose indication was cancer screening in most cases. The mean?±?SD age was 57.9?±?13.0?years with 20/36 females. Fourteen patients had a disease duration of less than 2?years. A third had anti-centromere antibodies and 27.8% had anti-topoisomerase antibodies. Pulmonary FDG uptakes were higher in SSc patients than in controls (n?=?89), especially in those with ILD compared with those without ILD. Pulmonary FDG uptakes were positively correlated with the ILD severity (fibrosis extent, %FVC, and %DLCO). No significant difference was found in the FDG uptakes from extrathoracic ROIs. Progressing SSc-ILDs within the 2?years after PET/CT (n?=?9) had significant higher pulmonary FDG uptakes at baseline than stable SSc-ILDs (n?=?13).Conclusion
PET/CT could be a useful tool in the assessment of the severity and the prediction of pulmonary function outcome of SSc-ILD.
SUBMITTER: Ledoult E
PROVIDER: S-EPMC7936499 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Ledoult Emmanuel E Morelle Maxime M Soussan Michael M Mékinian Arsène A Béhal Hélène H Sobanski Vincent V Hachulla Eric E Huglo Damien D Le Gouellec Noémie N Remy-Jardin Martine M Baillet Clio C Launay David D
Arthritis research & therapy 20210306 1
<h4>Background</h4>Interstitial lung disease is a common complication of systemic sclerosis (SSc-ILD), and it remains difficult to accurately predict its course. Progressing ILD could be more metabolically active, suggesting that the <sup>18</sup>F-FDG tracer could be a tool in the managing of SSc-ILD.<h4>Methods</h4>In our center, SSc patients and controls (non-Hodgkin lymphoma cured after first-line regimen) who had received a PET/CT were screened retrospectively. The FDG uptake (visual intens ...[more]