Adverse outcomes associated with rapid linear and non-linear patterns of chronic kidney disease progression.

ABSTRACT:

Background

Patients with rapidly declining renal function face the dual threat of end-stage renal disease (ESRD) and mortality prior to ESRD. What is less well characterised is whether the pattern of the renal trajectory, linear or non-linear, unmasks subgroups of rapidly progressing patients that face adverse outcomes in a differential manner.

Methods

An individual eGFR slope was applied to all outpatient estimated glomerular filtration rate (eGFR) values for each patient in the Salford Kidney Study from 2002 to 2018 who had at least 2 years follow-up, ≥4 eGFR values and baseline eGFR 15 to < 60 ml/min/1.73m². Rapid progression was defined as an annual eGFR slope of ≤ - 3 ml/min/1.73m²/yr and patients were categorised as linear or non-linear progressor

SUBMITTER: Ali I 

PROVIDER: S-EPMC7937251 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature