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Review: Lessons Learned From Clinical Trials Using Antimicrobial Peptides (AMPs).

ABSTRACT: Antimicrobial peptides (AMPs) or host defense peptides protect the host against various pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory properties ranging from the modulation of inflammatory responses to the promotion of wound healing. More interestingly, AMPs cause cell disruption through non-specific interactions with the membrane surface of pathogens. This is most likely responsible for the low or limited emergence of bacterial resistance against many AMPs. Despite the increasing number of antibiotic-resistant bacteria and the potency of novel AMPs to combat such pathogens, only a few AMPs are in clinical use. Therefore, the current review describes (i) the potential of AMPs as alternatives to antibiotics, (ii) the challenges toward clinical implementation of AMPs and (iii) strategies to improve the success rate of AMPs in clinical trials, emphasizing the lessons we could learn from these trials.

SUBMITTER: Dijksteel GS

PROVIDER: S-EPMC7937881 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Review: Lessons Learned From Clinical Trials Using Antimicrobial Peptides (AMPs).

Dijksteel Gabrielle S GS Ulrich Magda M W MMW Middelkoop Esther E Boekema Bouke K H L BKHL

Frontiers in microbiology 20210222

Antimicrobial peptides (AMPs) or host defense peptides protect the host against various pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory properties ranging from the modulation of inflammatory responses to the promotion of wound healing. More interestingly, AMPs cause cell disruption through non-specific interactions with the membrane surface of pathogens. This is most likely responsible for the low or limited emergence of bacterial resistance against many ...[more]

PMID: 33692766

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