Ontology highlight
ABSTRACT:
SUBMITTER: Palla AR
PROVIDER: S-EPMC7938328 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Palla A R AR Ravichandran M M Wang Y X YX Alexandrova L L Yang A V AV Kraft P P Holbrook C A CA Schürch C M CM Ho A T V ATV Blau H M HM
Science (New York, N.Y.) 20201210 6528
Treatments are lacking for sarcopenia, a debilitating age-related skeletal muscle wasting syndrome. We identifed increased amounts of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the prostaglandin E<sub>2</sub> (PGE<sub>2</sub>)-degrading enzyme, as a hallmark of aged tissues, including skeletal muscle. The consequent reduction in PGE<sub>2</sub> signaling contributed to muscle atrophy in aged mice and results from 15-PGDH-expressing myofibers and interstitial cells, such as macrophages, wit ...[more]