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Evidence for familial clustering in breast cancer age of onset.


ABSTRACT:

Background

Familial clustering of age at onset would have implications for both personalized screening and aetiology, but has not been studied for breast cancer.

Methods

We prospectively studied a cohort of 23 145 sisters to explore whether their breast cancer risk changed near the age at diagnosis of a previously affected older sister. Using an age-time-dependent variable in a Cox regression model, we estimated hazard ratios for breast cancer when participants were near their sister's diagnosis age, relative to similarly aged women whose sister was diagnosed at a very different age. To rule out a correlation driven by young-onset familial cancer, we separately investigated women who had enrolled at age 50 or older.

Results

Of the 23 145 women, 1412 developed breast cancer during follow-up (median 9.5?years). The estimated hazard ratio was 1.80 (95% confidence interval: 1.18, 2.74) at their sister's age at diagnosis, suggesting a substantial increase in risk compared with women of the same age but whose sister was diagnosed at a very different age. Restriction to women who enrolled at or after age 50 produced similar results.

Conclusions

This familial clustering suggests that there may be important genetic and/or early environmental risk factors that influence the timing of breast cancer, even when onset is late in life. Personalized screening might need to account for the age at which a sister was earlier diagnosed with breast cancer.

SUBMITTER: Von Holle A 

PROVIDER: S-EPMC7938508 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Evidence for familial clustering in breast cancer age of onset.

Von Holle Ann A   O'Brien Katie M KM   Sandler Dale P DP   Weinberg Clarice R CR  

International journal of epidemiology 20210301 1


<h4>Background</h4>Familial clustering of age at onset would have implications for both personalized screening and aetiology, but has not been studied for breast cancer.<h4>Methods</h4>We prospectively studied a cohort of 23 145 sisters to explore whether their breast cancer risk changed near the age at diagnosis of a previously affected older sister. Using an age-time-dependent variable in a Cox regression model, we estimated hazard ratios for breast cancer when participants were near their sis  ...[more]

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