CDCA8 as an independent predictor for a poor prognosis in liver cancer.

ABSTRACT:

Background

Human cell division cycle associated 8 (CDCA8) a key regulator of mitosis, has been described as a potential prognostic biomarker for a variety of cancers, such as breast, colon and lung cancers. We aimed to evaluate the potential role of CDCA8 expression in the prognosis of liver cancer by analysing data from The Cancer Genome Atlas (TCGA).

Methods

The Wilcoxon rank-sum test was used to compare the difference in CDCA8 expression between liver cancer tissues and matched normal tissues. Then, we applied logistic regression and the Wilcoxon rank-sum test to identify the association between CDCA8 expression and clinicopathologic characteristics. Cox regression and the Kaplan-Meier method were used to examine the clinicopathologic features correlated with overall surv

SUBMITTER: Shuai Y 

PROVIDER: S-EPMC7938604 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature