A five-year longitudinal study reveals progressive cortical thinning in narcolepsy and faster cortical thinning in relation to early-onset.
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ABSTRACT:
SUBMITTER: Jeon S
PROVIDER: S-EPMC7938668 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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A five-year longitudinal study reveals progressive cortical thinning in narcolepsy and faster cortical thinning in relation to early-onset.
Jeon Seun S Cho Jae Wook JW Kim Hosung H Evans Alan C AC Hong Seung Bong SB Joo Eun Yeon EY
Brain imaging and behavior 20200201 1
Narcolepsy with cataplexy is characterized by excessive daytime sleepiness, cataplexy, and other REM sleep phenomena. Previous MRI studies were cross-sectional in design and could not adequately address if disease progression leads the brain structural abnormalities in narcolepsy. Our analysis in patients using longitudinally collected brain MRIs (n = 17; 2 scans per patient; scan interval: 4.7 ± 1.9 years) revealed widespread progressive cortical thinning in bilateral dorsolateral frontal and f ...[more]
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