Ontology highlight
ABSTRACT:
SUBMITTER: Tilley FC
PROVIDER: S-EPMC7940485 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20210308 1
Several studies have reported WDR73 mutations to be causative of Galloway-Mowat syndrome, a rare disorder characterised by the association of neurological defects and renal-glomerular disease. In this study, we demonstrate interaction of WDR73 with the INTS9 and INTS11 components of Integrator, a large multiprotein complex with various roles in RNA metabolism and transcriptional control. We implicate WDR73 in two Integrator-regulated cellular pathways; namely, the processing of uridylate-rich sm ...[more]