Ontology highlight
ABSTRACT:
SUBMITTER: Kim TY
PROVIDER: S-EPMC7941009 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Kim Tae Yoon TY Cha Jeong Seok JS Kim Hoyoung H Choi Yoonjoo Y Cho Hyun-Soo HS Kim Hak-Sung HS
Computational and structural biotechnology journal 20210227
A protein binder with a desired epitope and binding affinity is critical to the development of therapeutic agents. Here we present computationally-guided design and affinity improvement of a protein binder recognizing a specific site on domain IV of human epidermal growth factor receptor 2 (HER2). As a model, a protein scaffold composed of Leucine-rich repeat (LRR) modules was used. We designed protein binders which appear to bind a target site on domain IV using a computational method. Top 10 d ...[more]