Localization and hypersecretion of nerve growth factor in breast phyllodes tumors: Evidence from a preliminary study.

ABSTRACT:

Background

The pathophysiology of the breast phyllodes tumors is uncertain. Currently, wide surgical removal is the only available treatment option. The histopathological diagnosis of phyllodes tumors is often confused with that of fibroadenomas due to a striking histological resemblance.

Aim

To identify a distinctive biomarker for phyllodes tumors of the breast.

Methods and results

Fresh human breast tissue was obtained from surgically excised breast phyllodes and fibroadenoma tumors (test), breast cancer (positive control) and normal breast tissue (negative control). Immunohistochemistry and Sandwich ELISA were performed for the detection of nerve growth factor (NGF) in test and control tissues. A marked difference in NGF expression was detected in phyllodes tumors

SUBMITTER: Kumar A 

PROVIDER: S-EPMC7941588 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature