Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Rocamora VM
PROVIDER: S-EPMC7943195 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
eLife 20210224
Peptidoglycan is an essential component of the bacterial cell envelope that surrounds the cytoplasmic membrane to protect the cell from osmotic lysis. Important antibiotics such as β-lactams and glycopeptides target peptidoglycan biosynthesis. Class A penicillin-binding proteins (PBPs) are bifunctional membrane-bound peptidoglycan synthases that polymerize glycan chains and connect adjacent stem peptides by transpeptidation. How these enzymes work in their physiological membrane environment is p ...[more]