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Environmental impact assessment of COVID-19 therapeutic solutions. A prospective analysis.

ABSTRACT: Several medicinal products for human use are currently under consideration as potential treatment for COVID-19 pandemic. As proposals cover also prophylactic use, the treatment could be massive, resulting in unprecedent levels of antiviral emissions to the aquatic environment. We have adapted previous models and used available information for predicting the environmental impact of representative medicinal products, covering the main groups under consideration: multitarget antiparasitic (chloroquines and ivermectin), glucocorticoids, macrolide antibiotics and antiviral drugs including their pharmacokinetic boosters. The retrieved information has been sufficient for conducting a conventional environmental risk assessment for the group of miscellaneous medicines; results suggest low concern for the chloroquines and dexamethasone while very high impact for ivermectin and azithromycin, even at use levels well below the default value of 1% of the population. The information on the ecotoxicity of the antiviral medicines is very scarce, thus we have explored an innovative pharmacodynamic-based approach, combining read-across, quantitative structure-activity relationship (QSAR), US EPA's Toxicity Forecaster (ToxCast) in vitro data, pharmacological modes of action, and the observed adverse effects. The results highlight fish sublethal effects as the most sensitive target and identify possible concerns. These results offer guidance for minimizing the environmental risk of treatment medication for COVID-19.

SUBMITTER: Tarazona JV

PROVIDER: S-EPMC7943388 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Environmental impact assessment of COVID-19 therapeutic solutions. A prospective analysis.

Tarazona José V JV Martínez Marta M Martínez María-Aránzazu MA Anadón Arturo A Anadón Arturo A

The Science of the total environment 20210310

Several medicinal products for human use are currently under consideration as potential treatment for COVID-19 pandemic. As proposals cover also prophylactic use, the treatment could be massive, resulting in unprecedent levels of antiviral emissions to the aquatic environment. We have adapted previous models and used available information for predicting the environmental impact of representative medicinal products, covering the main groups under consideration: multitarget antiparasitic (chloroqu ...[more]

PMID: 33721651

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Project description:The corona virus disease pandemic (COVID-19) is one of the recent issues that spread in the world, which disrupted life, impacted the economy, and led to heavy losses, whether for government sectors or private companies. This paper focuses on the Kuwait public transport company KPTC and Kuwait Airways' experience during the pandemic, since they incurred major losses due to the decline of their users. Public transport is a place to catch COVID-19, as it is subjected to the use of a large number of passengers daily within a small closed environment. The causes that led to the spread of the virus among public transport users and develop solutions to limit its spread and preserve public transport pioneer's safety were discussed in the paper. Additionally, the environmental impact resulting from the reduction of public transportation using was also addressed. Data was obtained from the KPTC, Kuwait Airways office, the Ministry of Health (MOH) database, and the Environment Public Authority (EPA) database. A questionnaire was distributed to public transport users to determine the reasons for the decline in its user's number and their aspirations to reconsider their use and ensure their satisfaction. For airplane data, the risk of importation of COVID-19 was calculated. For KPTC data, COVID-19 impact on the emissions generated per passenger-km was computed where the emissions were estimated by MOVES. The survey responses were statically analyzed using the chi-square test on the SPSS program, and they were compared to numerical analysis results. The results showed the impact of COVID-19 on people's willingness to use public transportation which was associated with the increase in the number of buses to implement social distancing has negatively affected the environment. Thus, a comprehensive strategy solution was presented consisting of three basic approaches: providing a healthy, risk-free environment for public transportation users, achieving social distancing at a low cost to offset the losses, and ensuring a healthy environment.

Dataset Information

Environmental impact assessment of COVID-19 therapeutic solutions. A prospective analysis.

Publications

Environmental impact assessment of COVID-19 therapeutic solutions. A prospective analysis.

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