Unknown

Dataset Information

0

Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era.


ABSTRACT: Enterococcus faecalis is a commensal and nosocomial pathogen, which is also ubiquitous in animals and insects, representing a classical generalist microorganism. Here, we study E. faecalis isolates ranging from the pre-antibiotic era in 1936 up to 2018, covering a large set of host species including wild birds, mammals, healthy humans, and hospitalised patients. We sequence the bacterial genomes using short- and long-read techniques, and identify multiple extant hospital-associated lineages, with last common ancestors dating back as far as the 19th century. We find a population cohesively connected through homologous recombination, a metabolic flexibility despite a small genome size, and a stable large core genome. Our findings indicate that the apparent hospital adaptations found in hospital-associated E. faecalis lineages likely predate the "modern hospital" era, suggesting selection in another niche, and underlining the generalist nature of this nosocomial pathogen.

SUBMITTER: Pontinen AK 

PROVIDER: S-EPMC7943827 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

2016-03-16 | GSE79250 | GEO
| S-EPMC2738112 | biostudies-literature
2010-08-01 | E-TABM-905 | biostudies-arrayexpress
2016-03-16 | E-GEOD-79250 | biostudies-arrayexpress
| S-EPMC4872833 | biostudies-literature
| S-EPMC7724050 | biostudies-literature
| S-EPMC2766626 | biostudies-literature
| S-EPMC3811304 | biostudies-literature
| S-EPMC3203883 | biostudies-literature
| S-EPMC9489580 | biostudies-literature