Ontology highlight
ABSTRACT:
SUBMITTER: Celorrio M
PROVIDER: S-EPMC7944629 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Celorrio Marta M Abellanas Miguel A MA Rhodes James J Goodwin Victoria V Moritz Jennie J Vadivelu Sangeetha S Wang Leran L Rodgers Rachel R Xiao Sophia S Anabayan Ilakkia I Payne Camryn C Perry Alexandra M AM Baldridge Megan T MT Aymerich Maria S MS Steed Ashley A Friess Stuart H SH
Acta neuropathologica communications 20210310 1
The influence of the gut microbiota on traumatic brain injury (TBI) is presently unknown. This knowledge gap is of paramount clinical significance as TBI patients are highly susceptible to alterations in the gut microbiota by antibiotic exposure. Antibiotic-induced gut microbial dysbiosis established prior to TBI significantly worsened neuronal loss and reduced microglia activation in the injured hippocampus with concomitant changes in fear memory response. Importantly, antibiotic exposure for 1 ...[more]