The potential significance of high avidity immunoglobulin G (IgG) for protective immunity towards SARS-CoV-2.

ABSTRACT:

Background

Avidity is defined as the strength of binding between immunoglobulin G (IgG) and its specific target epitope. IgG of high avidity is established during affinity maturation. Failure to achieve high avidity IgG may result in a lack of protective immunity towards infection and disease. It is known that the interaction between SARS-CoV-2 spike protein and its cellular receptor is driven by high affinity. Therefore, it is predictable that protective antibodies towards SARS-CoV-2 should show high affinity/avidity. AVIDITY AFTER SARS-COV-2 INFECTION: Recent findings by several groups demonstrate that the serological response towards infection with SARS-CoV-2 and seasonal coronaviruses is characterized by incomplete avidity maturation, followed by a decline of the serological re

SUBMITTER: Bauer G 

PROVIDER: S-EPMC7944804 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature